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Brain activity, regional gray matter loss, and decision-making in multiple sclerosis

Item Type:Article
Title:Brain activity, regional gray matter loss, and decision-making in multiple sclerosis
Creators Name:Weygandt, M. and Wakonig, K. and Behrens, J. and Meyer-Arndt, L. and Söder, E. and Brandt, A.U. and Bellmann-Strobl, J. and Ruprecht, K. and Gold, S.M. and Haynes, J.D. and Paul, F.
Abstract:BACKGROUND: Decision-making (DM) abilities deteriorate with multiple sclerosis (MS) disease progression which impairs everyday life and is thus clinically important. OBJECTIVE: To investigate the underlying neurocognitive processes and their relation to regional gray matter (GM) loss induced by MS. METHODS: We used a functional magnetic resonance imaging (fMRI) Iowa Gambling Task to measure DM-related brain activity in 36 MS patients and 21 healthy controls (HC). From this activity, we determined neural parameters of two cognitive stages, a deliberation ("choice") period preceding a choice and a post-choice ("feedback") stage reporting decision outcomes. These measures were related to DM separately in intact and damaged GM areas as determined by a voxel-based morphometry analysis. RESULTS: Severely affected patients (with high lesion burden) showed worse DM-learning than HC ( t = -1.75, p = 0.045), moderately affected (low lesion burden) did not. Activity in the choice stage in intact insular ( t = 4.60, pFamily-Wise Error [FWE] corrected = 0.034), anterior cingulate ( t = 4.50, pFWE = 0.044), and dorsolateral prefrontal areas ( t = 4.43, pFWE = 0.049) and in insular areas with GM loss ( t = 3.78, pFWE = 0.011) was positively linked to DM performance across patients with severe tissue damage and HC. Furthermore, activity in intact orbitofrontal areas was positively linked to DM-learning during the feedback stage across these participants ( t = 4.49, pFWE = 0.032). During none of the stages, moderately affected patients showed higher activity than HC, which might have indicated preserved DM due to compensatory activity. CONCLUSION: We identified dysregulated activity linked to impairment in specific cognitive stages of reward-related DM. The link of brain activity and impaired DM in areas with MS-induced GM loss suggests that this deficit might be tightly coupled to MS neuropathology.
Keywords:Multiple Sclerosis, Decision-Making, Functional Magnetic Resonance Imaging, Iowa Gambling Task, Brain Activity, Gray Matter Loss
Source:Multiple Sclerosis Journal
ISSN:1352-4585
Publisher:Sage Publications (U.K.)
Volume:24
Number:9
Page Range:1163-1173
Date:1 August 2018
Official Publication:https://doi.org/10.1177/1352458517717089
PubMed:View item in PubMed

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