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Breaking TADs: how alterations of chromatin domains result in disease

Item Type:Review
Title:Breaking TADs: how alterations of chromatin domains result in disease
Creators Name:Lupiáñez, D.G. and Spielmann, M. and Mundlos, S.
Abstract:Spatial organization is an inherent property of the vertebrate genome to accommodate the roughly 2m of DNA in the nucleus of a cell. In this nonrandom organization, topologically associating domains (TADs) emerge as a fundamental structural unit that is thought to guide regulatory elements to their cognate promoters. In this review we summarize the most recent findings about TADs and the boundary regions separating them. We discuss how the disruption of these structures by genomic rearrangements can result in gene misexpression and disease.
Keywords:Topologically Associating Domains, TAD, Long-Range Regulation, Structural Variations, CRISPR/Cas, Disease
Source:Trends in Genetics
Publisher:Elsevier (The Netherlands)
Page Range:225-237
Date:April 2016
Official Publication:https://doi.org/10.1016/j.tig.2016.01.003
PubMed:View item in PubMed

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