Vasculitis: a CLEAR argument for targeting complement in ANCA vasculitis

Item Type:	Editorial
Title:	Vasculitis: a CLEAR argument for targeting complement in ANCA vasculitis
Creators Name:	Kettritz, R.
Abstract:	Mechanistic studies have implicated the alternative complement pathway, specifically C5a receptor activation, in the pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis. Results from a phase 2 trial suggest that C5a receptor blockade could enable the reduced use or complete withdrawal of steroids from induction protocols.
Keywords:	Anaphylatoxin C5a Receptor, Aniline Compounds, Anti-Inflammatory Agents, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Biomarkers, Combination Drug Therapy, Nipecotic Acids, Phase II as Topic Clinical Trials, Prednisolone, Treatment Outcome
Source:	Nature Reviews Nephrology
ISSN:	1759-5061
Publisher:	Nature Publishing Group
Volume:	13
Number:	8
Page Range:	448-450
Date:	August 2017
Official Publication:	https://doi.org/10.1038/nrneph.2017.69
PubMed:	View item in PubMed

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