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Vasculitis: a CLEAR argument for targeting complement in ANCA vasculitis

Item Type:Editorial
Title:Vasculitis: a CLEAR argument for targeting complement in ANCA vasculitis
Creators Name:Kettritz, R.
Abstract:Mechanistic studies have implicated the alternative complement pathway, specifically C5a receptor activation, in the pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis. Results from a phase 2 trial suggest that C5a receptor blockade could enable the reduced use or complete withdrawal of steroids from induction protocols.
Source:Nature Reviews Nephrology
ISSN:1759-5061
Publisher:Nature Publishing Group (U.S.A.)
Volume:13
Number:8
Page Range:448-450
Date:August 2017
Official Publication:https://doi.org/10.1038/nrneph.2017.69
PubMed:View item in PubMed

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