3 Tesla (23)Na magnetic resonance imaging during acute kidney injury

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Item Type:	Article
Title:	3 Tesla (23)Na magnetic resonance imaging during acute kidney injury
Creators Name:	Hammon, M., Grossmann, S., Linz, P., Seuss, H., Hammon, R., Rosenhauer, D., Janka, R., Cavallaro, A., Luft, F.C., Titze, J., Uder, M. and Dahlmann, A.
Abstract:	RATIONALE AND OBJECTIVES: Sodium and proton magnetic resonance imaging ((23)Na/(1)H-MRI) have shown that muscle and skin can store Na(+) without water. In chronic renal failure and in heart failure, Na(+) mobilization occurs, but is variable depending on age, dialysis vintage, and other features. Na(+) storage depots have not been studied in patients with acute kidney injury (AKI). MATERIALS AND METHODS: We studied 7 patients with AKI (mean age: 51.7 years; range: 25-84) and 14 age-matched and gender-matched healthy controls. All underwent (23)Na/(1)H-MRI at the calf. Patients were studied before and after acute hemodialysis therapy within 5-6 days. The (23)Na-MRI produced grayscale images containing Na(+) phantoms, which served to quantify Na(+) contents. A fat-suppressed inversion recovery sequence was used to quantify H2O content. RESULTS: Plasma Na(+) levels did not change. Mean Na(+) contents in muscle and skin did not significantly change following four to five cycles of hemodialysis treatment (before therapy: 32.7 +/- 6.9 and 44.2 +/- 13.5 mmol/L, respectively; after dialysis: 31.7 +/-10.2 and 42.8+/- 11.8 mmol/L, respectively; P > .05). Water content measurements did not differ significantly before and after hemodialysis in muscle and skin (P > .05). Na(+) contents in calf muscle and skin of patients before hemodialysis were significantly higher than in healthy subjects (16.6+/-2.1 and 17.9+/-3.2) and remained significantly elevated after hemodialysis. CONCLUSIONS: Na(+) in muscle and skin accumulates in patients with AKI and, in contrast to patients receiving chronic hemodialysis and those with acute heart failure, is not mobilized with hemodialysis within 5-6 days.
Keywords:	Sodium, Muscle, Skin, Magnetic Resonance Imaging, Acute Renal Failure, Acute Renal Injury, Hemodialysis, Therapy Monitoring, 3 Tesla
Source:	Academic Radiology
ISSN:	1076-6332
Publisher:	Elsevier
Volume:	24
Number:	9
Page Range:	1086-1093
Date:	September 2017
Official Publication:	https://doi.org/10.1016/j.acra.2017.03.012
PubMed:	View item in PubMed

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