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Excitatory microcircuits within superficial layers of the medial entorhinal cortex

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Item Type:Article
Title:Excitatory microcircuits within superficial layers of the medial entorhinal cortex
Creators Name:Winterer, J. and Maier, N. and Wozny, C. and Beed, P. and Breustedt, J. and Evangelista, R. and Peng, Y. and D'Albis, T. and Kempter, R. and Schmitz, D.
Abstract:The distinctive firing pattern of grid cells in the medial entorhinal cortex (MEC) supports its role in the representation of space. It is widely believed that the hexagonal firing field of grid cells emerges from neural dynamics that depend on the local microcircuitry. However, local networks within the MEC are still not sufficiently characterized. Here, applying up to eight simultaneous whole-cell recordings in acute brain slices, we demonstrate the existence of unitary excitatory connections between principal neurons in the superficial layers of the MEC. In particular, we find prevalent feed-forward excitation from pyramidal neurons in layer III and layer II onto stellate cells in layer II, which might contribute to the generation or the inheritance of grid cell patterns.
Keywords:Entorhinal Cortex, Excitatory Postsynaptic Potentials, Nerve Net, Pyramidal Cells, Animals, Rats, Rats, Wistar
Source:Cell Reports
ISSN:2211-1247
Publisher:Cell Press / Elsevier (U.S.A.)
Volume:19
Number:6
Page Range:1110-1116
Date:9 May 2017
Official Publication:https://doi.org/10.1016/j.celrep.2017.04.041
PubMed:View item in PubMed

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