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Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia

Item Type:Article
Title:Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia
Creators Name:Ehrlich, L. and Hoeller, A. and Golic, M. and Herse, F. and Perschel, F.H. and Henrich, W. and Dechend, R. and Huppertz, B. and Verlohren, S.
Abstract:OBJECTIVE: To investigate whether differences between late-onset preeclampsia (PE) and intrauterine growth restriction (IUGR) can be explained by differential placental expression patters of sFlt-1, Flt-1, and placental growth factor (PlGF). METHODS: Placental tissues and maternal blood samples from seven patients with PE, five IUGR, and seven age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity. RESULTS: Placental PlGF mRNA and protein expression were not altered by placental dysfunction while placental villous trophoblast expression intensity of PlGF was increased. CONCLUSION: High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.
Keywords:Preeclampsia, Intra Uterine Growth Restriction, Placental Growth Factor, PIGF, Souble Fms-Like Tyrosine Kinase, SFlt1
Source:Hypertension in Pregnancy
ISSN:1064-1955
Publisher:Informa Healthcare (U.S.A.)
Volume:36
Number:2
Page Range:175-185
Date:May 2017
Official Publication:https://doi.org/10.1080/10641955.2017.1291673
PubMed:View item in PubMed

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