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Epigenome-wide association studies without the need for cell-type composition

Item Type:Article
Title:Epigenome-wide association studies without the need for cell-type composition
Creators Name:Zou, J. and Lippert, C. and Heckerman, D. and Aryee, M. and Listgarten, J.
Abstract:In epigenome-wide association studies, cell-type composition often differs between cases and controls, yielding associations that simply tag cell type rather than reveal fundamental biology. Current solutions require actual or estimated cell-type composition--information not easily obtainable for many samples of interest. We propose a method, FaST-LMM-EWASher, that automatically corrects for cell-type composition without the need for explicit knowledge of it, and then validate our method by comparison with the state-of-the-art approach. Corresponding software is available from http://www.microsoft.com/science/.
Keywords:Cells, Epigenomics, Genome-Wide Association Study, Linear Models
Source:Nature Methods
Publisher:Nature Publishing Group
Page Range:309-311
Date:March 2014
Official Publication:https://doi.org/10.1038/nmeth.2815
PubMed:View item in PubMed

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