Epigenome-wide association studies without the need for cell-type composition

Item Type:	Article
Title:	Epigenome-wide association studies without the need for cell-type composition
Creators Name:	Zou, J. and Lippert, C. and Heckerman, D. and Aryee, M. and Listgarten, J.
Abstract:	In epigenome-wide association studies, cell-type composition often differs between cases and controls, yielding associations that simply tag cell type rather than reveal fundamental biology. Current solutions require actual or estimated cell-type composition--information not easily obtainable for many samples of interest. We propose a method, FaST-LMM-EWASher, that automatically corrects for cell-type composition without the need for explicit knowledge of it, and then validate our method by comparison with the state-of-the-art approach. Corresponding software is available from http://www.microsoft.com/science/.
Keywords:	Cells, Epigenomics, Genome-Wide Association Study, Linear Models
Source:	Nature Methods
ISSN:	1548-7091
Publisher:	Nature Publishing Group
Volume:	11
Number:	3
Page Range:	309-311
Date:	March 2014
Official Publication:	https://doi.org/10.1038/nmeth.2815
PubMed:	View item in PubMed

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