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Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment

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Item Type:Article
Title:Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment
Creators Name:Mattei, D. and Ivanov, A. and Ferrai, C. and Jordan, P. and Guneykaya, D. and Buonfiglioli, A. and Schaafsma, W. and Przanowski, P. and Deuther-Conrad, W. and Brust, P. and Hesse, S. and Patt, M. and Sabri, O. and Ross, T.L. and Eggen, B.J.L. and Boddeke, E.W.G.M. and Kaminska, B. and Beule, D. and Pombo, A. and Kettenmann, H. and Wolf, S.A.
Abstract:Maternal immune activation (MIA) during pregnancy has been linked to an increased risk of developing psychiatric pathologies in later life. This link may be bridged by a defective microglial phenotype in the offspring induced by MIA, as microglia have key roles in the development and maintenance of neuronal signaling in the central nervous system. The beneficial effects of the immunomodulatory treatment with minocycline on schizophrenic patients are consistent with this hypothesis. Using the MIA mouse model, we found an altered microglial transcriptome and phagocytic function in the adult offspring accompanied by behavioral abnormalities. The changes in microglial phagocytosis on a functional and transcriptional level were similar to those observed in a mouse model of Alzheimer's disease hinting to a related microglial phenotype in neurodegenerative and psychiatric disorders. Minocycline treatment of adult MIA offspring reverted completely the transcriptional, functional and behavioral deficits, highlighting the potential benefits of therapeutic targeting of microglia in psychiatric disorders.
Keywords:Adult Children, Alzheimer Disease, Anti-Bacterial Agents, Behavior, Animal, Disease Models, Animal, Immune System Phenomena, Microglia, Minocycline, Phagocytosis, Pregnancy, Schizophrenia, Synaptic Transmission, Transcriptome, Animals, Mice
Source:Translational Psychiatry
ISSN:2158-3188
Publisher:Nature Publishing Group (U.S.A.)
Volume:7
Number:5
Page Range:e1120
Date:9 May 2017
Official Publication:https://doi.org/10.1038/tp.2017.80
PubMed:View item in PubMed

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