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Nanotubes, the fast track to treatment of Dent disease?

Item Type:Editorial
Title:Nanotubes, the fast track to treatment of Dent disease?
Creators Name:Willnow, T.E.
Abstract:Studies in mice have suggested bone marrow transplantation as a strategy to correct the endocytic dysfunction of the proximal tubules in renal Fanconi syndrome, yet the mode of action has remained mysterious. Using a mouse model of Dent disease, Gabriel et al. now show that rescue of the resorptive capacity in the diseased kidney involves cell-to-cell contact between engrafted and host cells via nanotubes, cellular projections that enable transfer of wild-type activity into mutant cells of the proximal tubule.
Keywords:Animal Disease Models, Dent Disease, Fanconi Syndrome, Nanotubes, Proximal Kidney Tubules, Animals, Mice
Source:Kidney International
Publisher:Elsevier (U.S.A.)
Page Range:776-778
Date:April 2017
Official Publication:https://doi.org/10.1016/j.kint.2016.12.030
PubMed:View item in PubMed

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