Nanotubes, the fast track to treatment of Dent disease?

Item Type:	Editorial
Title:	Nanotubes, the fast track to treatment of Dent disease?
Creators Name:	Willnow, T.E.
Abstract:	Studies in mice have suggested bone marrow transplantation as a strategy to correct the endocytic dysfunction of the proximal tubules in renal Fanconi syndrome, yet the mode of action has remained mysterious. Using a mouse model of Dent disease, Gabriel et al. now show that rescue of the resorptive capacity in the diseased kidney involves cell-to-cell contact between engrafted and host cells via nanotubes, cellular projections that enable transfer of wild-type activity into mutant cells of the proximal tubule.
Keywords:	Animal Disease Models, Dent Disease, Fanconi Syndrome, Nanotubes, Proximal Kidney Tubules, Animals, Mice
Source:	Kidney International
ISSN:	0085-2538
Publisher:	Elsevier
Volume:	91
Number:	4
Page Range:	776-778
Date:	April 2017
Official Publication:	https://doi.org/10.1016/j.kint.2016.12.030
PubMed:	View item in PubMed

Repository Staff Only: item control page