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Choosing wisely - Preclinical test models in the era of precision medicine

Item Type:Review
Title:Choosing wisely - Preclinical test models in the era of precision medicine
Creators Name:Klinghammer, K. and Walther, W. and Hoffmann, J.
Abstract:Through the introduction of a steadily growing variety of preclinical test models drug development and biomarker research has advanced. Next to classical used 2D cell line cultures, tissue-slice cultures, 3D organoid cell cultures, genetically engineered mouse models, cell line derived mouse models and patient derived xenografts may be selected for a specific question. All models harbor advantages and disadvantages. This review focuses on the available preclinical test models, novel developments such as humanized mice and discusses for which question a particular model should be employed.
Keywords:Preclinical Models, PDX, CDX, GEMMs, Tissue-Slice Cultures, Animals
Source:Cancer Treatment Reviews
ISSN:0305-7372
Publisher:Elsevier (U.K.)
Volume:55
Page Range:36-45
Date:April 2017
Official Publication:https://doi.org/10.1016/j.ctrv.2017.02.009
PubMed:View item in PubMed

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