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Massively parallel clonal analysis using CRISPR/Cas9 induced genetic scars

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Item Type:Preprint
Title:Massively parallel clonal analysis using CRISPR/Cas9 induced genetic scars
Creators Name:Junker, J.P. and Spanjaard, B. and Peterson-Maduro, J. and Alemany, A. and Hu, B. and Florescu, M. and van Oudenaarden, A.
Abstract:A key goal of developmental biology is to understand how a single cell transforms into a full-grown organism consisting of many cells. Although impressive progress has been made in lineage tracing using imaging approaches, analysis of vertebrate lineage trees has mostly been limited to relatively small subsets of cells. Here we present scartrace, a strategy for massively parallel clonal analysis based on Cas9 induced genetic scars in the zebrafish.
Source:bioRxiv
Publisher:Cold Spring Harbor Laboratory (U.S.A.)
Article Number:056499
Date:4 January 2017
Official Publication:https://doi.org/10.1101/056499

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