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Renal function is independently associated with circulating betatrophin

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Item Type:Article
Title:Renal function is independently associated with circulating betatrophin
Creators Name:Maurer, L. and Schwarz, F. and Fischer-Rosinsky, A. and Schlueter, N. and Brachs, S. and Moehlig, M. and Pfeiffer, A. and Mai, K. and Spranger, J. and Bobbert, T.
Abstract:OBJECTIVE: Betatrophin has been identified as a marker linking liver with beta cell function and lipid metabolism in murine models. Until now, the regulation of circulating betatrophin in humans is not entirely clear. We here analyzed the relation of betatrophin levels to phenotypes of the metabolic syndrome and speculated that renal function might influence circulating betatrophin levels and explain age-dependent changes of betatrophin. SUBJECTS: We analyzed blood samples from 535 individuals participating in the Metabolic Syndrome Berlin Potsdam study. RESULTS: In a crude analysis we found a positive correlation between betatrophin levels and HbA1c (r = 0.24; p < 0.001), fasting glucose (r = 0.20; p < 0.001) and triglycerides (r = 0.12; p = 0.007). Furthermore betatrophin was positively correlated with age (r = 0.47; p <0.001), systolic blood pressure (r = 0.17; p < 0.001), intima media thickness (r = 0.26; p < 0.001) and negatively correlated with CKD-EPI eGFR (r = -0.33; p < 0.001) as an estimate of renal function. Notably, eGFR remained highly associated with betatrophin after adjustment for age, waist circumference, gender, HbA1c and lipid parameters in a multivariate linear regression model ({beta} = -0.197, p< 0.001). CONCLUSIONS: Our data suggest that circulating levels of betatrophin depend on age, gender, waist circumference, total/HDL cholesterol ratio and renal function. Especially the association to eGFR highlights the importance for future studies to address renal function as possible influence on betatrophin regulation and consider eGFR as potential confounder when analyzing the role of betatrophin in humans.
Keywords:Blood Glucose, Blood Pressure, Carotid Intima-Media Thickness, Epidermal Growth Factor Receptor, Glucose Tolerance Test, Glycosylated Hemoglobin A, Kidney, Lipid Metabolism, Metabolic Syndrome X, Peptide Hormones, Triglycerides
Source:PLoS ONE
Publisher:Public Library of Science
Page Range:e0173197
Date:3 March 2017
Official Publication:https://doi.org/10.1371/journal.pone.0173197
PubMed:View item in PubMed

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