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Placental expression of sFlt-1 and PlGF in early preeclampsia vs. early IUGR vs. age-matched healthy pregnancies

Item Type:Article
Title:Placental expression of sFlt-1 and PlGF in early preeclampsia vs. early IUGR vs. age-matched healthy pregnancies
Creators Name:Hoeller, A. and Ehrlich, L. and Golic, M. and Herse, F. and Perschel, F.H. and Siwetz, M. and Henrich, W. and Dechend, R. and Huppertz, B. and Verlohren, S.
Abstract:Objective: To investigate whether differences between early preeclampsia and early fetal growth restriction can be explained by differential placental expression patterns of sFlt-1, Flt-1, and PlGF. Methods: Placental tissues and maternal blood samples from six cases of preeclampsia, seven IUGR, and six age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity. Results: Neither placental PlGF mRNA and protein expression nor placental villous trophoblast expression intensity of PlGF was altered by placental dysfunction. Conclusion: High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.
Keywords:sFlt-1/PlGF, sFlt-1, PlGF, Preeclampsia, Intrauterine Growth Restriction
Source:Hypertension in Pregnancy
ISSN:1064-1955
Publisher:Informa Healthcare (U.S.A.)
Volume:36
Number:2
Page Range:151-160
Date:May 2017
Official Publication:https://doi.org/10.1080/10641955.2016.1273363
PubMed:View item in PubMed

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