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Prevalence of metabolic syndrome in female and male patients at risk of psychosis

Item Type:Article
Title:Prevalence of metabolic syndrome in female and male patients at risk of psychosis
Creators Name:Cordes, J. and Bechdolf, A. and Engelke, C. and Kahl, K.G. and Balijepalli, C. and Loesch, C. and Klosterkoetter, J. and Wagner, M. and Maier, W. and Heinz, A. and de Millas, W. and Gaebel, W. and Winterer, G. and Janssen, B. and Schmidt-Kraepelin, C. and Schneider, F. and Lambert, M. and Juckel, G. and Wobrock, T. and Riedel, M. and Moebus, S.
Abstract:Metabolic Syndrome (MetS) is one of the most common factors underlying the high rate of mortality observed in patients with schizophrenia. Recent research on this topic revealed that many of the patients studied were, in fact, in a medicated state. As such, it is unclear whether MetS is causally associated with the disorder itself or the medication used to treat it. In this study, patients with a clinically high risk of expressing first episode psychosis (CHR) were examined regarding the prevalence of MetS. N=144 unmedicated and antipsychotic-naïve CHR patients, aged between 18 and 42years and suffering from unmanifested prodromal symptoms, were compared with a cohort of N=3995 individuals from the "German Metabolic and Cardiovascular Risk Study" (GEMCAS). A slightly higher prevalence of individual MetS criteria was observed in the CHR group compared to the GEMCAS sample; specifically, the following were noted: a higher blood pressure (35.0% vs. 28.0%), increased waist circumference (17.6% vs. 15.1%), and increased fasting blood glucose (9.4% vs. 4.0%) in CHR patients. Additionally, the rate of reduced HDL cholesterol concentrations was lower in the control group (20.2% vs. 13.3%).
Keywords:Metabolic Syndrome, First Episode Psychosis, Clinically High Risk Patients
Source:Schizophrenia Research
ISSN:0920-9964
Publisher:Elsevier (The Netherlands)
Volume:181
Page Range:38-42
Date:March 2017
Official Publication:https://doi.org/10.1016/j.schres.2016.09.012
PubMed:View item in PubMed

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