Bioinformatics analysis of functional associations of PTMs

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Item Type:	Article
Title:	Bioinformatics analysis of functional associations of PTMs
Creators Name:	Minguez, P. and Bork, P.
Abstract:	Post-translational modifications (PTMs) are an important source of protein regulation; they fine-tune the function, localization, and interaction with other molecules of the majority of proteins and are partially responsible for their multifunctionality. Usually, proteins have several potential modification sites, and their patterns of occupancy are associated with certain functional states. These patterns imply cross talk among PTMs within and between proteins, the majority of which are still to be discovered. Several methods detect associations between PTMs; these have recently combined into a global resource, the PTMcode database, which contains already known and predicted functional associations between pairs of PTMs from more than 45,000 proteins in 19 eukaryotic species.
Keywords:	Systems Biology, Proteomics, Protein Regulation, Post-Translational Modifications, Protein-Protein Interactions
Source:	Methods in Molecular Biology
Series Name:	Methods in Molecular Biology
Title of Book:	Protein Bioinformatics
ISSN:	1064-3745
ISBN:	978-1-4939-6783-4
Publisher:	Springer / Humana Press
Volume:	1558
Number:	1558
Page Range:	303-320
Number of Pages:	436
Date:	2 February 2017
Official Publication:	https://doi.org/10.1007/978-1-4939-6783-4_14
PubMed:	View item in PubMed

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