Helmholtz Gemeinschaft


Obesity and oesophageal cancer

Item Type:Article
Title:Obesity and oesophageal cancer
Creators Name:Nimptsch, K. and Steffen, A. and Pischon, T.
Abstract:A substantial increase in the incidence of oesophageal adenocarcinoma has been observed in Western countries during the past 30 years, which may be related to the parallel rise of the obesity prevalence. On the other hand, incidence rates of oesophageal squamous cell carcinomas, the other major histological type of oesophageal cancer, have remained relatively stable. Epidemiological research of the past decades has identified obesity as risk factor for oesophageal adenocarcinoma. Studies investigating general obesity as assessed by body mass index (BMI) provide evidence for a strong positive association with oesophageal adenocarcinoma. Studies investigating abdominal obesity in relation to oesophageal adenocarcinoma observed also positive associations, which may be independent of general obesity. Some studies indicate that early life obesity is also associated with higher risk of oesophageal adenocarcinoma, but it is as to date unclear whether these associations are independent of adult obesity. Part of the positive association between obesity and oesophageal adenocarcinoma may be explained through obesity-related mechanical promotion of gastroesophageal reflux disease, which is one of the main risk factors for oesophageal adenocarcinoma. Other lines of evidence point to an independent role of metabolic pathways modulating cell proliferation, apoptosis and cell growth such as pro-inflammatory cytokines, adipokines and insulin resistance, the role of which in oesophageal carcinogenesis is, however, as to date insufficiently understood. Studies investigating obesity in relation to squamous cell carcinoma observed inverse relationships, but the underlying mechanisms remain unclear.
Keywords:Obesity, Oesophageal Cancer, Oesophageal Adenocarcinoma, Gastro-Oesophageal Reflux Disease
Source:Recent Results in Cancer Research
Series Name:Recent Results in Cancer Research
Title of Book:Obesity and Cancer
Page Range:67-80
Number of Pages:256
Date:2 December 2016
Official Publication:https://doi.org/10.1007/978-3-319-42542-9_4
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library