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Lipidome determinants of maximal lifespan in mammals

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Item Type:Article
Title:Lipidome determinants of maximal lifespan in mammals
Creators Name:Bozek, K. and Khrameeva, E.E. and Reznick, J. and Omerbašić, D. and Bennett, N.C. and Lewin, G.R. and Azpurua, J. and Gorbunova, V. and Seluanov, A. and Regnard, P. and Wanert, F. and Marchal, J. and Pifferi, F. and Aujard, F. and Liu, Z. and Shi, P. and Pääbo, S. and Schroeder, F. and Willmitzer, L. and Giavalisco, P. and Khaitovich, P.
Abstract:Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationship between maximal lifespan duration and concentrations of more than 20,000 lipid compounds, measured in 669 tissue samples from 6 tissues of 35 species representing three mammalian clades: primates, rodents and bats. We identify lipids associated with species' longevity across the three clades, uncoupled from other parameters, such as basal metabolic rate, body size, or body temperature. These lipids clustered in specific lipid classes and pathways, and enzymes linked to them display signatures of greater stabilizing selection in long-living species, and cluster in functional groups related to signaling and protein-modification processes. These findings point towards the existence of defined molecular mechanisms underlying variation in maximal lifespan among mammals.
Keywords:Lipids, Longevity, Metabolic Networks and Pathways, Animals, Chiroptera, Primates, Rodentia
Source:Scientific Reports
Publisher:Nature Publishing Group
Page Range:5
Date:31 January 2017
Additional Information:Erratum in: Sci Rep 9(1): 6972.
Official Publication:https://doi.org/10.1038/s41598-017-00037-7
PubMed:View item in PubMed

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