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Targeted basic research to highlight the role of estrogen and estrogen receptors in the cardiovascular system

Item Type:Review
Title:Targeted basic research to highlight the role of estrogen and estrogen receptors in the cardiovascular system
Creators Name:Dworatzek, E. and Mahmoodzadeh, S.
Abstract:Epidemiological, clinical and animal studies revealed that sex differences exist in the manifestation and outcome of cardiovascular disease (CVD). The underlying molecular mechanisms implicated in these sex differences are not fully understood. The reasons for sex differences in CVD are definitely multifactorial, but major evidence points to the contribution of sex steroid hormone, 17β-estradiol (E2), and its receptors, estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). In this review, we summarize past and present studies that implicate E2 and ER as important determinants of sexual dimorphism in the physiology and pathophysiology of the heart. In particular, we give an overview of studies aimed to reveal the role of E2 and ER in the physiology of the observed sex differences in CVD using ER knock-out mice. Finally, we discuss recent findings from novel transgenic mouse models, which have provided new information on the sexual dimorphic roles of ER specifically in cardiomyocytes under pathological conditions.
Keywords:Sex Differences, Estrogen, Estrogen Receptor, Cardiovascular Disease, Animals, Mice
Source:Pharmacological Research
ISSN:1043-6618
Publisher:Elsevier / Academic Press (U.K.)
Volume:119
Page Range:27-35
Date:May 2017
Official Publication:https://doi.org/10.1016/j.phrs.2017.01.019
PubMed:View item in PubMed

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