Helmholtz Gemeinschaft


MicroRNAs: an adaptive mechanism in the pancreatic β-cell…and beyond?

PDF (accepted manuscript (final draft)) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader

Item Type:Article
Title:MicroRNAs: an adaptive mechanism in the pancreatic β-cell…and beyond?
Creators Name:Poy, M.N.
Abstract:Recent protocols have been developed to differentiate human stem cells and fibroblasts into insulin-producing cells capable of releasing the hormone in a glucose-stimulated manner. Limitations remain which prevent bringing these protocols to a clinical setting as these models must still undergo complete characterization. Advances in sequencing technologies have driven the identification of several non-coding RNA species including microRNAs (miRNAs). While their diversity and unique expression patterns across different tissues have made deciphering their precise functional role a significant challenge, studies using both cell lines and transgenic mouse models have made substantial progress in understanding their regulatory role on exocytosis and proliferation of the {beta}-cell. These results also indicate miRNAs play an integral role in the fundamental mechanics of how the cell manages the balance between these independent functions. Continued investigation into miRNA function may uncover mechanisms which can be exploited to improve differentiation protocols in producing fully mature {beta}-cells.
Keywords:Pancreatic Islet, Metabolic Stress, Diabetes, Beta Cell Profileration, Instulin Secretion, Non-Coding RNA, Animals
Source:Best Practice & Research Clinical Endocrinology & Metabolism
Page Range:621-628
Date:October 2016
Official Publication:https://doi.org/10.1016/j.beem.2016.07.003
PubMed:View item in PubMed

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library