Patients with multiple sclerosis demonstrate reduced subbasal corneal nerve fibre density

Item Type:	Article
Title:	Patients with multiple sclerosis demonstrate reduced subbasal corneal nerve fibre density
Creators Name:	Mikolajczak, J. and Zimmermann, H. and Kheirkhah, A. and Kadas, E.M. and Oberwahrenbrock, T. and Muller, R. and Ren, A. and Kuchling, J. and Dietze, H. and Prüss, H. and Paul, F. and Hamrah, P. and Brandt, A.U.
Abstract:	BACKGROUND: Many studies in multiple sclerosis (MS) have investigated the retina. Little, however, is known about the effect of MS on the cornea, which is innervated by the trigeminal nerve. It is the site of neural-immune interaction with local dendritic cells reacting in response to environmental stimuli. OBJECTIVE: This study aims to investigate the effect of MS on corneal nerve fibres and dendritic cells in the subbasal nerve plexus using in vivo confocal microscopy (IVCM). METHODS: We measured the corneal nerve fibre and dendritic cell density in 26 MS patients and matched healthy controls using a Heidelberg Retina Tomograph with cornea module. Disease severity was assessed with the Multiple Sclerosis Functional Composite, Expanded Disability Status Scale, visual acuity and retinal optical coherence tomography. RESULTS: We observed significant reduction in total corneal nerve fibre density in MS patients compared to controls. Dendritic cell density was similar in both groups. Reduced total nerve fibre density was associated with worse clinical severity but not with previous clinical trigeminal symptoms, retinal neuro-axonal damage, visual acuity or disease duration. CONCLUSION: Corneal nerve fibre density is a promising new imaging marker for the assessment of disease severity in MS and should be investigated further.
Keywords:	Multiple Sclerosis, Cornea, Subbasal Nerve Plexus, Trigeminal Neuralgia, Peripheral Nerves, Retina
Source:	Multiple Sclerosis Journal
ISSN:	1352-4585
Publisher:	Sage Publications
Volume:	23
Number:	14
Page Range:	1847-1853
Date:	1 December 2017
Additional Information:	Copyright © The Author(s), 2016.
Official Publication:	https://doi.org/10.1177/1352458516677590
External Fulltext:	View full text on PubMed Central
PubMed:	View item in PubMed

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