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OGEE v2: an update of the online gene essentiality database with special focus on differentially essential genes in human cancer cell lines

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Item Type:Article
Title:OGEE v2: an update of the online gene essentiality database with special focus on differentially essential genes in human cancer cell lines
Creators Name:Chen, W.H., Lu, G., Chen, X., Zhao, X.M. and Bork, P.
Abstract:OGEE is an Online GEne Essentiality database. To enhance our understanding of the essentiality of genes, in OGEE we collected experimentally tested essential and non-essential genes, as well as associated gene properties known to contribute to gene essentiality. We focus on large-scale experiments, and complement our data with text-mining results. We organized tested genes into data sets according to their sources, and tagged those with variable essentiality statuses across data sets as conditionally essential genes, intending to highlight the complex interplay between gene functions and environments/experimental perturbations. Developments since the last public release include increased numbers of species and gene essentiality data sets, inclusion of non-coding essential sequences and genes with intermediate essentiality statuses. In addition, we included 16 essentiality data sets from cancer cell lines, corresponding to 9 human cancers; with OGEE, users can easily explore the shared and differentially essential genes within and between cancer types. These genes, especially those derived from cell lines that are similar to tumor samples, could reveal the oncogenic drivers, paralogous gene expression pattern and chromosomal structure of the corresponding cancer types, and can be further screened to identify targets for cancer therapy and/or new drug development. OGEE is freely available at http://ogee.medgenius.info.
Keywords:Cell Line, Tumor, Databases, Nucleic Acid, Gene Expression Regulation, Neoplastic, Genes, Essential, Neoplasms, Oncogenes, Search Engine, Software, User-Computer Interface, Web Browser
Source:Nucleic Acids Research
ISSN:0305-1048
Publisher:Oxford University Press
Volume:45
Number:D1
Page Range:D940-D944
Date:4 January 2017
Official Publication:https://doi.org/10.1093/nar/gkw1013
PubMed:View item in PubMed

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