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A kinome of 2600 in the ciliate Paramecium tetraurelia

Item Type:Article
Title:A kinome of 2600 in the ciliate Paramecium tetraurelia
Creators Name:Bemm, F. and Schwarz, R. and Foerster, F. and Schultz, J.
Abstract:Protein kinases play a crucial role in the regulation of cellular processes. Most eukaryotes reserve about 2.5% of their genes for protein kinases. We analysed the genome of the single-celled ciliate Paramecium tetraurelia and identified 2606 kinases, about 6.6% of its genes, representing the largest kinome to date. A gene tree combined with human kinases revealed a massive expansion of the calcium calmodulin regulated subfamily, underlining the importance of calcium in the physiology of P. tetraurelia. The kinases are embedded in only 40 domain architectures, contrasting 134 in human. This might indicate different mechanisms to achieve target specificity.
Keywords:Kinase, Genome, Sequence Analysis, Domain, Animals, Paramecium Tetraurelia
Source:FEBS Letters
ISSN:0014-5793
Publisher:Elsevier (The Netherlands)
Volume:583
Number:22
Page Range:3589-3592
Date:19 November 2009
Official Publication:https://doi.org/10.1016/j.febslet.2009.10.029
PubMed:View item in PubMed

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