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| Item Type: | Article | ||||
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| Title: | Changes in postural syntax characterize sensory modulation and natural variation of C. elegans locomotion | ||||
| Creators Name: | Schwarz, R.F. and Branicky, R. and Grundy, L.J. and Schafer, W.R. and Brown, A.E.X. | ||||
| Abstract: | Locomotion is driven by shape changes coordinated by the nervous system through time; thus, enumerating an animal's complete repertoire of shape transitions would provide a basis for a comprehensive understanding of locomotor behaviour. Here we introduce a discrete representation of behaviour in the nematode C. elegans. At each point in time, the worm's posture is approximated by its closest matching template from a set of 90 postures and locomotion is represented as sequences of postures. The frequency distribution of postural sequences is heavy-tailed with a core of frequent behaviours and a much larger set of rarely used behaviours. Responses to optogenetic and environmental stimuli can be quantified as changes in postural syntax: worms show different preferences for different sequences of postures drawn from the same set of templates. A discrete representation of behaviour will enable the use of methods developed for other kinds of discrete data in bioinformatics and language processing to be harnessed for the study of behaviour. | ||||
| Keywords: | Animal Behavior, Cluster Analysis, Computational Biology, Locomotion, Optogenetics, Animals, Caenorhabditis elegans | ||||
| Source: | PLoS Computational Biology | ||||
| ISSN: | 1553-734X | ||||
| Publisher: | Public Library of Science | ||||
| Volume: | 11 | ||||
| Number: | 8 | ||||
| Page Range: | e1004322 | ||||
| Date: | 21 August 2015 | ||||
| Official Publication: | https://doi.org/10.1371/journal.pcbi.1004322 | ||||
| PubMed: | View item in PubMed | ||||
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