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Polycomb and lung cancer: when the dosage makes the (kind of) poison

Item Type:Article
Title:Polycomb and lung cancer: when the dosage makes the (kind of) poison
Creators Name:Gargiulo, G. and Citterio, E. and Serresi, M.
Abstract:The Polycomb transcriptional repressors regulate normal tissue homeostasis and their function is often hijacked during oncogenesis. We recently uncovered the Polycomb repressive complex-2 (PRC2) genes Ezh2 and Eed as oncogenotype-dependent cancer genes. Notably, within the same oncogenotype, PRC2 dosage modulates lung tumor homeostasis and critically impacts non-tumor tissue function.
Keywords:Epigenetics, Ezh2, Inflammation, Kras, Lung Cancer, p53, Polycomb
Source:Molecular & Cellular Oncology
ISSN:2372-3556
Publisher:Taylor & Francis (U.S.A.)
Volume:3
Number:3
Page Range:e1152345
Date:May 2016
Official Publication:https://doi.org/10.1080/23723556.2016.1152345
PubMed:View item in PubMed

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