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OPA1 functionally interacts with MIC60 but is dispensable for crista junction formation

Item Type:Article
Title:OPA1 functionally interacts with MIC60 but is dispensable for crista junction formation
Creators Name:Barrera, M. and Koob, S. and Dikov, D. and Vogel, F. and Reichert, A.S.
Abstract:Remodeling of crista junctions (CJs) is observed in numerous human disorders and during apoptosis. The functional interplay of OPA1 and MIC60, two key players in this context, is unclear. We show that OPA1 modulates cristae morphology but is dispensable for CJ formation. MIC60 is strongly enriched at CJs whereas OPA1 is distributed evenly across the inner membrane. MIC60 levels are increased in OPA1(-/-) cells which show increased cellular resistance to apoptosis induction. Endogenous OPA1 and MIC60 show a physical interaction. Overall, we suggest that the regulation of CJ remodeling during apoptosis is mediated via an interplay between OPA1 and MIC60.
Keywords:Apoptosis, Crista Junction, MICOS, Mitochondria, Mitofilin, Animals, Mice
Source:FEBS Letters
ISSN:0014-5793
Publisher:Wiley-Blackwell (U.K.)
Volume:590
Number:19
Page Range:3309-3322
Date:October 2016
Official Publication:https://doi.org/10.1002/1873-3468.12384
PubMed:View item in PubMed

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