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The persistent dynamic secrets of senescence

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Official URL:https://doi.org/10.1038/ncb3403
PubMed:View item in PubMed
Creators Name:Schmitt, C.A.
Journal Title:Nature Cell Biology
Journal Abbreviation:Nat Cell Biol
Volume:18
Number:9
Page Range:913-915
Date:September 2016
Abstract:While the beneficial versus detrimental implications of the senescence-associated secretome remain an issue of debate, time-resolved analyses of its composition, regulatory mechanisms and functional consequences have been largely missing. The dynamic activity of NOTCH is now shown to direct two distinct senescence phenotypes, by first promoting a pro-senescent TGF-{beta}1-dependent secretome, followed by a second wave of pro-inflammatory, senescence-clearing cytokines.
ISSN:1465-7392
Publisher:Nature Publishing Group (U.K.)
Item Type:Editorial

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