Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

The persistent dynamic secrets of senescence

[img]
Preview
PDF (Accepted manuscript) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
321kB

Item Type:Editorial
Title:The persistent dynamic secrets of senescence
Creators Name:Schmitt, C.A.
Abstract:While the beneficial versus detrimental implications of the senescence-associated secretome remain an issue of debate, time-resolved analyses of its composition, regulatory mechanisms and functional consequences have been largely missing. The dynamic activity of NOTCH is now shown to direct two distinct senescence phenotypes, by first promoting a pro-senescent TGF-{beta}1-dependent secretome, followed by a second wave of pro-inflammatory, senescence-clearing cytokines.
Keywords:Cell Aging, Fibroblasts, Intracellular Signaling Peptides and Proteins, Neoplasms, Notch Receptors, Animals
Source:Nature Cell Biology
ISSN:1465-7392
Publisher:Nature Publishing Group (U.K.)
Volume:18
Number:9
Page Range:913-915
Date:September 2016
Official Publication:https://doi.org/10.1038/ncb3403
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library