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Organ-specific alteration in caspase expression and STK3 proteolysis during the aging process

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Item Type:Article
Title:Organ-specific alteration in caspase expression and STK3 proteolysis during the aging process
Creators Name:Lessard-Beaudoin, M. and Laroche, M. and Loudghi, A. and Demers, M.J. and Denault, J.B. and Grenier, G. and Riechers, S.P. and Wanker, E.E. and Graham, R.K.
Abstract:Caspases and their substrates are key mediators of apoptosis and strongly implicated in various physiological processes. As the serine/threonine kinase family is involved in apoptosis and serine/threonine kinase 3 (STK3) is a recently identified caspase-6 substrate, we assessed the expression and cleavage of STK3 in murine peripheral organs and brain regions during the aging process. We also assessed caspase-3, -6, -7, and -8 expression and activity in order to delineate potential mechanism(s) underlying the generation of the STK3 fragments observed and their relation to the apoptotic pathway. We demonstrate for the first time the cleavage of STK3 by caspase-7 and show that STK3 protein levels globally increase throughout the organism with age. In contrast, caspase-3, -6, -7, and -8 expression and activity vary significantly among the different organs analyzed suggesting differential effects of aging on the apoptotic mechanism and/or nonapoptotic functions of caspases throughout the organism. These results further our understanding of the role of caspases and their substrates in the normal aging process and highlight a potential role for STK3 in neurodegeneration.
Keywords:Aging, Apoptosis, Caspases, Serine/Threonine Kinase 3, Peripheral Organs, Brain Region, Animals, Mice
Source:Neurobiology of Aging
ISSN:0197-4580
Publisher:Elsevier (The Netherlands)
Volume:47
Page Range:50-62
Date:November 2016
Official Publication:https://doi.org/10.1016/j.neurobiolaging.2016.07.003
PubMed:View item in PubMed

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