Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

TAK1 adaptor proteins TAB2 and TAB3 link the signalosome to B cell receptor-induced IKK activation

Item Type:Article
Title:TAK1 adaptor proteins TAB2 and TAB3 link the signalosome to B cell receptor-induced IKK activation
Creators Name:Shinohara, H. and Yasuda, T. and Kurosaki, T.
Abstract:Transforming growth factor-{beta}-activated kinase (TAK)1-binding proteins (TAB) activate nuclear factor-{kappa}B by linking TAK1 to signaling molecules. We investigated the mechanisms underlying B cell receptor (BCR) signaling in TAB2- and TAB3-deficient and TAB3 domain deletion mutant DT40 B cell lines. Loss of TAB2 or TAB3 abolished BCR-induced inhibitor of {kappa}B kinase (IKK) activation and TAK1 binding to caspase recruitment domain membrane-associated guanylate kinase protein (CARMA)1. Deletion of TAB3, coupling of ubiquitin conjugation to ER degradation, coiled-coil, and zinc finger domains blocked IKK activation and association with CARMA1. Thus, TAB2 and TAB3 connect signaling molecules that activate IKK in BCR signaling.
Keywords:BCR Signaling, TAK1, TAB, IKK, DT40 B Cells, Gene Targeting, Animals, Chickens
Source:FEBS Letters
ISSN:0014-5793
Publisher:Wiley-Blackwell (U.K.)
Volume:590
Number:18
Page Range:3264-3269
Date:September 2016
Official Publication:https://doi.org/10.1002/1873-3468.12342
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library