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Environmental factors in autoimmune diseases and their role in multiple sclerosis

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Item Type:Review
Title:Environmental factors in autoimmune diseases and their role in multiple sclerosis
Creators Name:Jörg, S. and Grohme, D.A. and Erzler, M. and Binsfeld, M. and Haghikia, A. and Müller, D.N. and Linker, R.A. and Kleinewietfeld, M.
Abstract:An increase in autoimmune diseases poses a socioeconomic challenge worldwide. Predisposing genetic risk has been identified, yet environmental factors make up a significant part of the risk in disease initiation and propagation. Next to improved hygiene and a gross reduction of infections, changes in dietary habits are one of the most evident Western lifestyle factors potentially associated with the increase in autoimmune diseases. Growing evidence suggests that particularly a typical 'Western diet', rich in saturated fat and salt and related pathologies can have a profound impact on local and systemic immune responses under physiologic and autoimmune conditions such as in multiple sclerosis (MS). In this review, we discuss recent findings on environmental factors influencing autoimmunity with an emphasis on the impact of 'Western diet' on immune homeostasis and gut microbiota in MS.
Keywords:Autoimmunity, MS, CD4+ T Cells, Foxp3+ Tregs, Th17 Cells, Environmental Risk Factors, Microbiota, Animals
Source:Cellular and Molecular Life Sciences
ISSN:1420-682X
Publisher:Springer / Birkhauser (Switzerland)
Volume:73
Number:24
Page Range:4611-4622
Date:December 2016
Official Publication:https://doi.org/10.1007/s00018-016-2311-1
PubMed:View item in PubMed

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