Helmholtz Gemeinschaft


Cardiac transcription factors and regulatory networks

Item Type:Book Section
Title:Cardiac transcription factors and regulatory networks
Creators Name:Grunert, M. and Dorn, C. and Rickert-Sperling, S.
Abstract:Cardiac development is a fine-tuned process governed by complex transcriptional networks, in which transcription factors (TFs) interact with other regulatory layers. In this chapter, we first introduce the core cardiac TFs including Gata, Hand, Nkx2, Mef2 and Tbx, and Srf. These factors regulate each other’s expression and also can act in a combinatorial manner on their downstream targets. Their disruption leads to various cardiac phenotypes in mice, and mutations in humans have been associated with congenital heart defects. In the second part of the chapter, we discuss different levels of regulation including cis-regulatory elements, chromatin structure, and micro-RNAs, which can interact with transcription factors, modulate their function, or are downstream targets. Finally, examples of disturbances of the cardiac regulatory network leading to congenital heart diseases in human are provided.
Keywords:Transcription Factors, Gata4, Hand1, Hand2, Nkx2-5, Mef2, Tbx1, Tbx2, Tbx3, Tbx5, Tbx18, Tbx20, Srf, Cis-Regulatory Elements, Chromatin Structure, MicroRNAs, Transcriptional Network, Drosophila, Isl1, Tetralogy of Fallot, TOF, Left Ventricular Noncompaction, Double Outlet Right Ventricle, DORV, Ebstein’s Anomaly, MyoD, HDAC, HAT, Knockout Mice, Atrioventricular Septal Defects, AVSD, Truncus Arteriosus, Common Atrioventricular Canal, First Heart Field, Second Heart Field, FHF, SHF, Embryonic Stem Cells, Myocardin, ENCODE, Regulatory Elements, Enhancers, Silencers, Histone, DNA Methylation, miR-133, miR-143, miR-145, Notch1, Genome-Wide Association Studies, GWAS, SCN10A, SCN5A
Title of Book:Congenital Heart Diseases: The Broken Heart : Clinical Features, Human Genetics and Molecular Pathways
Page Range:139-152
Official Publication:https://doi.org/10.1007/978-3-7091-1883-2_12

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