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MRI phase changes in multiple sclerosis vs neuromyelitis optica lesions at 7T

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Item Type:Article
Title:MRI phase changes in multiple sclerosis vs neuromyelitis optica lesions at 7T
Creators Name:Sinnecker, T. and Schumacher, S. and Mueller, K. and Pache, F. and Dusek, P. and Harms, L. and Ruprecht, K. and Nytrova, P. and Chawla, S. and Niendorf, T. and Kister, I. and Paul, F. and Ge, Y. and Wuerfel, J.
Abstract:OBJECTIVE: To characterize paramagnetic MRI phase signal abnormalities in neuromyelitis optica spectrum disorder (NMOSD) vs multiple sclerosis (MS) lesions in a cross-sectional study. METHODS: Ten patients with NMOSD and 10 patients with relapsing-remitting MS underwent 7-tesla brain MRI including supratentorial T2*-weighted imaging and supratentorial susceptibility weighted imaging. Next, we analyzed intra- and perilesional paramagnetic phase changes on susceptibility weighted imaging filtered magnetic resonance phase images. RESULTS: We frequently observed paramagnetic rim-like (75 of 232 lesions, 32%) or nodular (32 of 232 lesions, 14%) phase changes in MS lesions, but only rarely in NMOSD lesions (rim-like phase changes: 2 of 112 lesions, 2%, p < 0.001; nodular phase changes: 2 of 112 lesions, 2%, p < 0.001). CONCLUSIONS: Rim-like or nodular paramagnetic MRI phase changes are characteristic for MS lesions and not frequently detectable in NMOSD. Future prospective studies should ask whether these imaging findings can be used as a biomarker to distinguish between NMOSD- and MS-related brain lesions.
Keywords:Substantia Nigra, Grey Matter, Pulvinar
Source:Neurology Neuroimmunology & Neuroinflammation
Publisher:American Academy of Neurology
Page Range:e259
Date:August 2016
Official Publication:https://doi.org/10.1212/NXI.0000000000000259
PubMed:View item in PubMed

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