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Acute effects of ferumoxytol on regulation of renal hemodynamics and oxygenation

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Item Type:Article
Title:Acute effects of ferumoxytol on regulation of renal hemodynamics and oxygenation
Creators Name:Cantow, K. and Pohlmann, A. and Flemming, B. and Ferrara, F. and Waiczies, S. and Grosenick, D. and Niendorf, T. and Seeliger, E.
Abstract:The superparamagnetic iron oxide nanoparticle ferumoxytol is increasingly used as intravascular contrast agent in magnetic resonance imaging (MRI). This study details the impact of ferumoxytol on regulation of renal hemodynamics and oxygenation. In 10 anesthetized rats, a single intravenous injection of isotonic saline (used as volume control) was followed by three consecutive injections of ferumoxytol to achieve cumulative doses of 6, 10, and 41 mg Fe/kg body mass. Arterial blood pressure, renal blood flow, renal cortical and medullary perfusion and oxygen tension were continuously measured. Regulation of renal hemodynamics and oxygenation was characterized by dedicated interventions: brief periods of suprarenal aortic occlusion, hypoxia, and hyperoxia. None of the three doses of ferumoxytol resulted in significant changes in any of the measured parameters as compared to saline. Ferumoxytol did not significantly alter regulation of renal hemodynamics and oxygenation as studied by aortic occlusion and hypoxia. The only significant effect of ferumoxytol at the highest dose was a blunting of the hyperoxia-induced increase in arterial pressure. Taken together, ferumoxytol has only marginal effects on the regulation of renal hemodynamics and oxygenation. This makes ferumoxytol a prime candidate as contrast agent for renal MRI including the assessment of renal blood volume fraction.
Keywords:Blood Pressure, Ferrosoferric Oxide, Hemodynamics, Hypoxia, Kidney, Oxygen Consumption, Renal Circulation, Animals, Rats
Source:Scientific Reports
ISSN:2045-2322
Publisher:Nature Publishing Group
Volume:6
Page Range:29965
Date:20 July 2016
Official Publication:https://doi.org/10.1038/srep29965
PubMed:View item in PubMed

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