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Specific metabolic markers are associated with future waist-gaining phenotype in women

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Item Type:Article
Title:Specific metabolic markers are associated with future waist-gaining phenotype in women
Creators Name:Merz, B. and Nöthlings, U. and Wahl, S. and Haftenberger, M. and Schienkiewitz, A. and Adamski, J. and Suhre, K. and Wang-Sattler, R. and Grallert, H. and Thorand, B. and Pischon, T. and Bachlechner, U. and Floegel, A. and Peters, A. and Boeing, H.
Abstract:Objective: Our study aims to identify metabolic markers associated with either a gain in abdominal (measured by waist circumference) or peripheral (measured by hip circumference) body fat mass. Methods: Data of 4 126 weight-gaining adults (18–75 years) from three population-based, prospective German cohort studies (EPIC, KORA, DEGS) were analysed regarding a waist-gaining (WG) or hip-gaining phenotype (HG). The phenotypes were obtained by calculating the differences of annual changes in waist minus hip circumference. The difference was displayed for all cohorts. The highest 10% of this difference were defined as WG whereas the lowest 10% were defined as HG. A total of 121 concordant metabolite measurements were conducted using Biocrates AbsoluteIDQ® kits in EPIC and KORA. Sex-specific associations with metabolite concentration as independent and phenotype as the dependent variable adjusted for confounders were calculated. The Benjamini-Hochberg method was used to correct for multiple testing. Results: Across studies both sexes gained on average more waist than hip circumference. We could identify 12 metabolites as being associated with the WG (n = 8) or HG (n = 4) in men, but none were significant after correction for multiple testing; 45 metabolites were associated with the WG (n = 41) or HG (n = 4) in women. For WG, n = 21 metabolites remained significant after correction for multiple testing. Respective odds ratios (OR) ranged from 0.66 to 0.73 for tryptophan, the diacyl-phosphatidylcholines (PC) C32:3, C36:0, C38:0, C38:1, C42:2, C42:5, the acyl-alkyl-PCs C32:2, C34:0, C36:0, C36:1, C36:2, C38:0, C38:2, C40:1, C40:2, C40:5, C40:6, 42:2, C42:3 and lyso-PC C17:0. Conclusion: Both weight-gaining men and women showed a clear tendency to gain more abdominal than peripheral fat. Gain of abdominal fat seems to be related to an initial metabolic state reflected by low concentrations of specific metabolites, at least in women. Thus, higher levels of specific PCs may play a protective role in gaining waist circumference.
Keywords:Biomarkers, Cohort Studies, Meta-Analysis as Topic, Metabolome, Phenotype, Waist Circumference, Waist-Hip Ratio, Weight Gain
Source:PLoS ONE
Publisher:Public Library of Science
Page Range:e0157733
Date:20 June 2016
Official Publication:https://doi.org/10.1371/journal.pone.0157733
PubMed:View item in PubMed

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