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| Item Type: | Article |
|---|---|
| Title: | Health-related quality of life in children and adolescents with hereditary bleeding disorders and in children and adolescents with stroke: cross-sectional comparison to siblings and peers |
| Creators Name: | Neuner, B. and von Mackensen, S. and Holzhauer, S. and Funk, S. and Klamroth, R. and Kurnik, K. and Kruempel, A. and Halimeh, S. and Reinke, S. and Fruehwald, M. and Nowak-Goettl, U. |
| Abstract: | Objectives: To investigate self-reported health-related quality of life (HrQoL) in children and adolescents with chronic medical conditions compared with siblings/peers. Methods: Group 1 (6 treatment centers) consisted of 74 children/adolescents aged 8-16 years with hereditary bleeding disorders (HBD), 12 siblings, and 34 peers. Group 2 (one treatment center) consisted of 70 children/adolescents with stroke/transient ischemic attack, 14 siblings, and 72 peers. HrQoL was assessed with the "revised KINDer Lebensqualitaetsfragebogen" (KINDL-R) questionnaire. Multivariate analyses within groups were done by one-way ANOVA and post hoc pairwise single comparisons by Student's t-tests. Adjusted pairwise comparisons were done by hierarchical linear regressions with individuals nested within treatment centers (group 1) and by linear regressions (group 2), respectively. Results: No differences were found in multivariate analyses of self-reported HrQoL in group 1, while in group 2 differences occurred in overall wellbeing and all subdimensions. These differences were due to differences between patients and peers. After adjusting for age, gender, number of siblings, and treatment center these differences persisted regarding self-worth (p = .0040) and friend-related wellbeing (p < .001). Conclusions: In children with HBD, HrQoL was comparable to siblings and peers. In children with stroke/TIA HrQoL was comparable to siblings while peers, independently of relevant confounder, showed better self-worth and friend-related wellbeing. |
| Keywords: | Blood Coagulation Disorders, Cross-Sectional Studies, Linear Models, Multivariate Analysis, Quality of Life, Siblings, Stroke, Surveys and Questionnaires |
| Source: | BioMed Research International |
| ISSN: | 2314-6133 |
| Publisher: | Hindawi |
| Volume: | 2016 |
| Page Range: | 1579428 |
| Date: | 15 May 2016 |
| Official Publication: | https://doi.org/10.1155/2016/1579428 |
| PubMed: | View item in PubMed |
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