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Translaminar cortical membrane potential synchrony in behaving mice

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Item Type:Article
Title:Translaminar cortical membrane potential synchrony in behaving mice
Creators Name:Zhao, W.J. and Kremkow, J. and Poulet, J.F.A.
Abstract:The synchronized activity of six layers of cortical neurons is critical for sensory perception and the control of voluntary behavior, but little is known about the synaptic mechanisms of cortical synchrony across layers in behaving animals. We made single and dual whole-cell recordings from the primary somatosensory forepaw cortex in awake mice and show that L2/3 and L5 excitatory neurons have layer-specific intrinsic properties and membrane potential dynamics that shape laminar-specific firing rates and subthreshold synchrony. First, while sensory and movement-evoked synaptic input was tightly correlated across layers, spontaneous action potentials and slow spontaneous subthreshold fluctuations had laminar-specific timing; second, longer duration forepaw movement was associated with a decorrelation of subthreshold activity; third, spontaneous and sensory-evoked forepaw movements were signaled more strongly by L5 than L2/3 neurons. Together, our data suggest that the degree of translaminar synchrony is dependent upon the origin (sensory, spontaneous, and movement) of the synaptic input.
Keywords:Animal Behavior, Extremities, Membrane Potentials, Movement, Physical Stimulation, Pyramidal Cells, Somatosensory Cortex, Synapses, Touch, Wakefulness, Animals, Mice
Source:Cell Reports
ISSN:2211-1247
Publisher:Cell Press / Elsevier (U.S.A.)
Volume:15
Number:11
Page Range:2387-2399
Date:14 June 2016
Official Publication:https://doi.org/10.1016/j.celrep.2016.05.026
PubMed:View item in PubMed

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