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Fine specificity of the antibody response to Epstein-Barr nuclear antigen-2 and other Epstein-Barr virus proteins in patients with clinically isolated syndrome: a peptide microarray-based case-control study

Item Type:Article
Title:Fine specificity of the antibody response to Epstein-Barr nuclear antigen-2 and other Epstein-Barr virus proteins in patients with clinically isolated syndrome: a peptide microarray-based case-control study
Creators Name:Schlemm, L. and Giess, R.M. and Rasche, L. and Pfuhl, C. and Wakonig, K. and Behrens, J.R. and Scheibenbogen, C. and Bellmann-Strobl, J. and Paul, F. and Reimer, U. and Ruprecht, K.
Abstract:We analyzed the fine specificity of antibodies to Epstein-Barr nuclear antigen-2 (EBNA-2) and other Epstein-Barr virus (EBV) proteins in 29 patients with clinically isolated syndrome (CIS, the first clinical manifestation of multiple sclerosis [MS]) and 29 controls with a peptide microarray containing 117 overlapping peptides representing the full-length EBNA-2 protein and 71 peptides from 8 further EBV proteins. While EBV peptide antibodies were elevated in CIS, suggesting that EBV contributes to MS early during disease development, they discriminated groups only slightly better than EBNA-1 antibodies. Thus, the additional value of EBV peptide antibodies as diagnostic biomarkers for CIS appears moderate.
Keywords:Multiple Sclerosis, Clinically Isolated Syndrome, Epstein-Barr Virus, Epstein-Barr Nuclear Antigen, Antibodies, Peptide Microarray, Animals, Mice
Source:Journal of Neuroimmunology
ISSN:0165-5728
Publisher:Elsevier (The Netherlands)
Volume:297
Page Range:56-62
Date:15 August 2016
Official Publication:https://doi.org/10.1016/j.jneuroim.2016.05.012
PubMed:View item in PubMed

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