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The time-of-day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment

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Item Type:Article
Title:The time-of-day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment
Creators Name:Schloss, M.J. and Horckmans, M. and Nitz, K. and Duchene, J. and Drechsler, M. and Bidzhekov, K. and Scheiermann, C. and Weber, C. and Soehnlein, O. and Steffens, S.
Abstract:Myocardial infarction (MI) is the leading cause of death in Western countries. Epidemiological studies show acute MI to be more prevalent in the morning and to be associated with a poorer outcome in terms of mortality and recovery. The mechanisms behind this association are not fully understood. Here, we report that circadian oscillations of neutrophil recruitment to the heart determine infarct size, healing, and cardiac function after MI Preferential cardiac neutrophil recruitment during the active phase (Zeitgeber time, ZT13) was paralleled by enhanced myeloid progenitor production, increased circulating numbers of CXCR2(hi) neutrophils as well as upregulated cardiac adhesion molecule and chemokine expression. MI at ZT13 resulted in significantly higher cardiac neutrophil infiltration compared to ZT5, which was inhibited by CXCR2 antagonism or neutrophil-specific CXCR2 knockout. Limiting exaggerated neutrophilic inflammation at this time point significantly reduced the infarct size and improved cardiac function.
Keywords:Circadian Rhythm, Fibrosis, Myocardial Infarction Healing, Neutrophils, Progenitors, Animals, Mice
Source:EMBO Molecular Medicine
ISSN:1757-4676
Publisher:EMBO Press
Volume:8
Number:8
Page Range:937-948
Date:1 August 2016
Official Publication:https://doi.org/10.15252/emmm.201506083
PubMed:View item in PubMed

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