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A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms

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Item Type:Article
Title:A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms
Creators Name:Choi, I.Y. and Piccio, L. and Childress, P. and Bollman, B. and Ghosh, A. and Brandhorst, S. and Suarez, J. and Michalsen, A. and Cross, A.H. and Morgan, T.E. and Wei, M. and Paul, F. and Bock, M. and Longo, V.D.
Abstract:Dietary interventions have not been effective in the treatment of multiple sclerosis (MS). Here, we show that periodic 3-day cycles of a fasting mimicking diet (FMD) are effective in ameliorating demyelination and symptoms in a murine experimental autoimmune encephalomyelitis (EAE) model. The FMD reduced clinical severity in all mice and completely reversed symptoms in 20% of animals. These improvements were associated with increased corticosterone levels and regulatory T (Treg) cell numbers and reduced levels of pro-inflammatory cytokines, TH1 and TH17 cells, and antigen-presenting cells (APCs). Moreover, the FMD promoted oligodendrocyte precursor cell regeneration and remyelination in axons in both EAE and cuprizone MS models, supporting its effects on both suppression of autoimmunity and remyelination. We also report preliminary data suggesting that an FMD or a chronic ketogenic diet are safe, feasible, and potentially effective in the treatment of relapsing-remitting multiple sclerosis (RRMS) patients (NCT01538355).
Keywords:Animal Disease Models, Antigens, Apoptosis, Autoimmunity, Biological Models, Diet, Experimental Autoimmune Encephalomyelitis, Fasting, Inbred C57BL Mice, Lymphocyte Count, Lymphocytes, Multiple Sclerosis, Myelin Sheath, Myelin-Oligodendrocyte Glycoprotein, Oligodendroglia, Peptide Fragments, Regeneration, Spinal Cord, Spleen, Animals
Source:Cell Reports
ISSN:2211-1247
Publisher:Cell Press / Elsevier (U.S.A.)
Volume:15
Number:10
Page Range:2136-2146
Date:7 June 2016
Official Publication:https://doi.org/10.1016/j.celrep.2016.05.009
PubMed:View item in PubMed

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