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ANP system activity predicts variability of fat mass reduction and insulin sensitivity during weight loss

Item Type:Article
Title:ANP system activity predicts variability of fat mass reduction and insulin sensitivity during weight loss
Creators Name:Brachs, M. and Wiegand, S. and Leupelt, V. and Ernert, A. and Kintscher, U. and Jumpertz von Schwarzenberg, R. and Decker, A.M. and Bobbert, T. and Hübner, N. and Chen, W. and Krude, H. and Spranger, J. and Mai, K.
Abstract:Introduction: In weight loss trials, a considerable inter-individual variability in reduction of fat mass and changes of insulin resistance is observed, even under standardized study conditions. The underlying mechanisms are not well understood. Given the metabolic properties of the atrial natriuretic peptide (ANP) system, we hypothesized that ANP signaling might be involved in this phenomenon by changes of ANP secretion or receptor balance. Therefore, we investigated the impact of systemic, adipose and myocellular ANP system on metabolic and anthropometric improvements during weight loss. Methods: We comprehensively investigated 143 subjects (31 male, 112 female) before and after a 3 month-standardized weight loss program. The time course of BMI, fat mass, insulin sensitivity, circulating mid-regional proANP (MR-proANP) levels as well as adipose and myocellular natriuretic receptor A (NPR-A) and C (NPR-C) mRNA expression were investigated. Results: BMI decreased by − 12.6 ± 3.7%. This was accompanied by a remarkable decrease of adipose NPR-C expression (1005.0 ± 488.4 vs. 556.7 ± 465.6; p < 0.001) as well as a tendency towards increased adipose NPR-A expression (4644.7 ± 946.8 vs. 4877.6 ± 869.8; p = 0.051). Weight loss induced changes in NPR-C ({delta}NPR-C) was linked to relative reduction of total fat mass ({delta}FM) (r = 0.281; p < 0.05), reduction of BMI (r = 0.277; p < 0.01), and increase of free fatty acids ({delta}FFA) (r = − 0.258; p < 0.05). Basal NPR-C expression and weight loss induced {delta}NPR-C independently explained 22.7% of {delta}FM. In addition, {delta}MR-proANP was independently associated with improvement of insulin sensitivity (standardized {beta} = 0.246, p < 0.01). Discussion: ANP receptor expression predicted the degree of weight loss induced fat mass reduction. Our comprehensive human data support that peripheral ANP signalling is involved in control of adipose tissue plasticity and function during weight loss. (Funded by the Deutsche Forschungsgemeinschaft (KFO281/2), the Berlin Institute of Health (BIH) and the German Centre for Cardiovascular Research (DZHK/BMBF); ClinicalTrials.gov number: NCT00850629).
Keywords:Weight Loss, ANP System, Fat Mass, Insulin Sensitivity
Source:Metabolism
ISSN:0026-0495
Publisher:Elsevier / Saunders (U.S.A.)
Volume:65
Number:6
Page Range:935-943
Date:June 2016
Official Publication:https://doi.org/10.1016/j.metabol.2016.03.013
PubMed:View item in PubMed

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