Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Prediction of preeclampsia with angiogenic biomarkers. Results from the prospective Odense Child Cohort

Item Type:Article
Title:Prediction of preeclampsia with angiogenic biomarkers. Results from the prospective Odense Child Cohort
Creators Name:Andersen, L.B. and Dechend, R. and Jørgensen, J.S. and Luef, B.M. and Nielsen, J. and Barington, T. and Christesen, H.T.
Abstract:OBJECTIVE: We aimed to investigate how maternal serum soluble Fms-like kinase 1 (sFlt-1), placental growth factor (PlGF), and sFlt-1/PlGF ratio prospectively associate to preeclampsia (PE) and clinical subtypes. METHODS: In an unselected cohort of 1909 pregnant women, sFlt-1 and PlGF were measured with KRYPTOR assays in gestational weeks (GW) 8-14 and 20-34. Associations to PE were assessed by receiver operating characteristics and logistic regression. RESULTS: Concentrations of sFlt-1, PlGF, and sFlt-1/PlGF in GW20-34 were predictive of PE development, but not in GW8-14. PlGF outperformed sFlt-1/PlGF ratio with an area under curve (AUC) of 0.755 vs. 0.704, p = 0.002. The highest AUC values for PlGF and sFlt-1/PlGF ratio were seen for severe early-onset PE (0.901 and 0.883). Negative predictive values were high for all PE types, but positive predictive values were low. CONCLUSION: PlGF and sFlt-1/PlGF had good predictive value for PE at GW20-34 in a population-based unselected cohort, however with low positive predictive value.
Keywords:PlGF, Prediction, Preeclampsia, Prenatal Screening, sFlt-1
Source:Hypertension in Pregnancy
ISSN:1064-1955
Publisher:Informa Healthcare (U.S.A.)
Volume:35
Number:3
Page Range:405-419
Date:August 2016
Official Publication:https://doi.org/10.3109/10641955.2016.1167219
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library