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Branched-chain and aromatic amino acids, insulin resistance and liver specific ectopic fat storage in overweight to obese subjects

Item Type:Article
Title:Branched-chain and aromatic amino acids, insulin resistance and liver specific ectopic fat storage in overweight to obese subjects
Creators Name:Haufe, S. and Witt, H. and Engeli, S. and Kaminski, J. and Utz, W. and Fuhrmann, J.C. and Rein, D. and Schulz-Menger, J. and Luft, F.C. and Boschmann, M. and Jordan, J.
Abstract:BACKGROUND & AIMS: Amino acids may interfere with insulin action, particularly in obese individuals. We hypothesized that increased circulating branched-chain and aromatic amino acids herald insulin resistance and ectopic fat storage, particularly hepatic fat accumulation. METHODS AND RESULTS: We measured fasting branched-chain and aromatic amino acids (tryptophan, tyrosine, and phenylalanine) by mass spectrometry in 111 overweight to obese subjects. We applied abdominal magnetic resonance imaging and spectroscopy to assess adipose tissue distribution and ectopic fat storage, respectively. Plasma branched-chain amino acids concentrations were related to insulin sensitivity and intrahepatic fat independent from adiposity, age and gender, but not to abdominal adipose tissue or intramyocellular fat. CONCLUSIONS: In weight stable overweight and obese individuals, branched-chain amino acid concentrations are specifically associated with hepatic fat storage and insulin resistance.
Keywords:Body Fat Distribution, Insulin Sensitivity, Intrahepatic Fat, Obesity
Source:Nutrition Metabolism and Cardiovascular Diseases
ISSN:0939-4753
Publisher:Elsevier (Italy)
Volume:26
Number:7
Page Range:637-642
Date:July 2016
Official Publication:https://doi.org/10.1016/j.numecd.2016.03.013
PubMed:View item in PubMed

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