Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner

Item Type:	Article
Title:	Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner
Creators Name:	Xu, X. and Meng, Q. and Erben, U. and Wang, P. and Glauben, R. and Kuehl, A.A. and Wu, H. and Ma, C.W. and Hu, M. and Wang, Y. and Sun, W. and Jia, J. and Wu, X. and Chen, W. and Siegmund, B. and Qin, Z.
Abstract:	Myeloid-derived suppressor cells (MDSCs) are well known for their capacity to suppress antitumor T-cell responses, but their effects on B-cell function and antibody production remain unclear. Here, we found that MDSCs that accumulated around the germinal center in the spleen of tumor-bearing mice co-located with B cells. In the presence of MDSCs, the antibody reaction to a surrogate antigen was significantly enhanced in mice, especially the immunoglobulin (Ig)A subtype. Co-culture with MDSCs promoted both proliferation and differentiation of B cells into IgA-producing plasma cells in vitro. Interestingly, the cross talk between MDSCs and B cells required cell-cell contact. MDSCs from tumor necrosis factor receptor (TNFR) 2(-/-) mice, but not from TNFR1(-/-) mice, failed to promote B-cell responses. Further investigation suggested that interleukin-10 and transforming growth factor-{beta}1 were crucial for the MDSC-mediated promotion of IgA responses. These results demonstrate a novel mechanism of MDSC-mediated immune regulation during tumor growth.
Keywords:	B Cells, IgA, MDSCs, TNFR2, Animals, Mice
Source:	Cellular and Molecular Immunology
ISSN:	1672-7681
Publisher:	Chinese Society of Immunology
Volume:	14
Number:	7
Page Range:	597-606
Date:	July 2017
Official Publication:	https://doi.org/10.1038/cmi.2015.103
PubMed:	View item in PubMed

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