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Durable coexistence of donor and recipient strains after fecal microbiota transplantation

Item Type:Article
Title:Durable coexistence of donor and recipient strains after fecal microbiota transplantation
Creators Name:Li, S.S. and Zhu, A. and Benes, V. and Costea, P.I. and Hercog, R. and Hildebrand, F. and Huerta-Cepas, J. and Nieuwdorp, M. and Salojaervi, J. and Voigt, A.Y. and Zeller, G. and Sunagawa, S. and de Vos, W.M. and Bork, P.
Abstract:Fecal microbiota transplantation (FMT) has shown efficacy in treating recurrent Clostridium difficile infection and is increasingly being applied to other gastrointestinal disorders, yet the fate of native and introduced microbial strains remains largely unknown. To quantify the extent of donor microbiota colonization, we monitored strain populations in fecal samples from a recent FMT study on metabolic syndrome patients using single-nucleotide variants in metagenomes. We found extensive coexistence of donor and recipient strains, persisting 3 months after treatment. Colonization success was greater for conspecific strains than for new species, the latter falling within fluctuation levels observed in healthy individuals over a similar time frame. Furthermore, same-donor recipients displayed varying degrees of microbiota transfer, indicating individual patterns of microbiome resistance and donor-recipient compatibilities.
Keywords:Bacteria, Clostridium Infections, Fecal Microbiota Transplantation, Feces, Gastrointestinal Microbiome, Homologous Transplantation, Symbiosis, Tissue Donors
Source:Science
ISSN:0036-8075
Publisher:American Association for the Advancement of Science (U.S.A.)
Volume:352
Number:6285
Page Range:586-589
Date:29 April 2016
Official Publication:https://doi.org/10.1126/science.aad8852
PubMed:View item in PubMed

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