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Orchestrating Wnt signalling for metabolic liver zonation

Official URL:https://doi.org/10.1038/ncb3349
PubMed:View item in PubMed
Creators Name:Birchmeier, W.
Journal Title:Nature Cell Biology
Journal Abbreviation:Nat Cell Biol
Volume:18
Number:5
Page Range:463-465
Date:May 2016
Keywords:Animals, Mice
Abstract:Wnt/{beta}-catenin signalling is an important regulator of liver development, zonation and regeneration. The cell surface complex RSPO-LGR4/5-ZNF3/RNF43 is now shown to direct Wnt/{beta}-catenin signalling in orchestrating the division of the liver into functionally distinct metabolic zones, providing insights into the mechanisms that influence organ development and regeneration.
ISSN:1465-7392
Publisher:Nature Publishing Group (U.K.)
Item Type:Editorial

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