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Immunoadsorption of agonistic autoantibodies against α1-adrenergic receptors in patients with mild to moderate dementia

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Item Type:Article
Title:Immunoadsorption of agonistic autoantibodies against α1-adrenergic receptors in patients with mild to moderate dementia
Creators Name:Hempel, P. and Heinig, B. and Jerosch, C. and Decius, I. and Karczewski, P. and Kassner, U. and Kunze, R. and Steinhagen-Thiessen, E. and Bimmler, M.
Abstract:Dementia has been shown to be associated with agonistic autoantibodies. The deleterious action of autoantibodies on the {alpha}1-adrenergic receptor for brain vasculature has been demonstrated in animal studies. In the current study, 169 patients with dementia were screened for the presence of agonistic autoantibodies. 47% of patients suffering from mild to moderate Alzheimer's disease and/or vascular dementia carried these autoantibodies. Eight patients positive for autoantibodies underwent immunoadsorption. Patients treated on four consecutive days were subsequently negative for autoantibodies and displayed stabilization of cognitive and mental condition during 12-18 months' follow-up. In patients treated for 2-3 days, autoantibodies were reduced by only 78%. They suffered a rebound of autoantibodies during follow-up, benefited from immunoadsorption too, but their mental parameters worsened. We provide first data on the clinical relevance of agonistic autoantibodies in dementia and show that immunoadsorption is safe and efficient in removing autoantibodies with overall benefits for patients.
Keywords:Autoantibodies, Brain Vasculature, Dementia, Immunoadsorption, {alpha}1-Adrenergic receptor
Source:Therapeutic Apheresis and Dialysis
Page Range:523-529
Date:October 2016
Official Publication:https://doi.org/10.1111/1744-9987.12415
PubMed:View item in PubMed

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