Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Neuromyelitis optica does not impact periventricular venous density versus healthy controls: a 7.0 Tesla MRI clinical study

[img]
Preview
PDF (Manuscript (final draft)) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
2MB
[img] Other (Supplementary Information)
9MB

Item Type:Article
Title:Neuromyelitis optica does not impact periventricular venous density versus healthy controls: a 7.0 Tesla MRI clinical study
Creators Name:Schumacher, S. and Pache, F. and Bellmann-Strobl, J. and Behrens, J. and Dusek, P. and Harms, L. and Ruprecht, K. and Nytrova, P. and Chawla, S. and Niendorf, T. and Kister, I. and Paul, F. and Ge, Y. and Wuerfel, J. and Sinnecker, T.
Abstract:Objective: To quantify the periventricular venous density in neuromyelitis optica spectrum disease (NMOSD) in comparison to that in patients with multiple sclerosis (MS) and healthy control subjects. Materials and methods: Sixteen patients with NMOSD, 16 patients with MS and 16 healthy control subjects underwent 7.0-Tesla (7T) MRI. The imaging protocol included T2*-weighted (T2*w) fast low angle-shot (FLASH) and fluid-attenuated inversion recovery (FLAIR) sequences. The periventricular venous area (PVA) was manually determined by a blinded investigator in order to estimate the periventricular venous density in a region of interest-based approach. Results: No significant differences in periventricular venous density indicated by PVA were detectable in NMOSD versus healthy controls (p = 0.226). In contrast, PVA was significantly reduced in MS patients compared to healthy controls (p = 0.013). Conclusion: Unlike patients with MS, those suffering from NMOSD did not show reduced venous visibility. This finding may underscore primary and secondary pathophysiological differences between these two distinct diseases of the central nervous system.
Keywords:Ultrahigh-Field MRI, 7T MRI, Multiple Sclerosis, Neuromyelitis Optica, Venous Density
Source:Magnetic Resonance Materials in Physics Biology and Medicine
ISSN:0968-5243
Publisher:Springer (U.S.A.)
Volume:29
Number:3
Page Range:535-541
Date:June 2016
Official Publication:https://doi.org/10.1007/s10334-016-0554-3
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library