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The route to spinal cord cell types: a tale of signals and switches

Item Type:Review
Title:The route to spinal cord cell types: a tale of signals and switches
Creators Name:Gouti, M. and Metzis, V. and Briscoe, J.
Abstract:Understanding the mechanisms that control induction and elaboration of the vertebrate central nervous system (CNS) requires an analysis of the extrinsic signals and downstream transcriptional networks that assign cell fates in the correct space and time. We focus on the generation and patterning of the spinal cord. We summarize evidence that the origin of the spinal cord is distinct from the anterior regions of the CNS. We discuss how this affects the gene regulatory networks and cell state transitions that specify spinal cord cell subtypes, and we highlight how the timing of extracellular signals and dynamic control of transcriptional networks contribute to the correct spatiotemporal generation of different neural cell types.
Keywords:Body Patterning, Central Nervous System, Developmental Gene Expression Regulation, Gene Regulatory Networks, Genetic Models, Germ Layers, SOXB1 Transcription Factors, Spinal Cord, Animals
Source:Trends in Genetics
Page Range:282-289
Date:June 2015
Official Publication:https://doi.org/10.1016/j.tig.2015.03.001
PubMed:View item in PubMed

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