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Bone marrow GvHD after allogeneic hematopoietic stem cell transplantation

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Item Type:Review
Title:Bone marrow GvHD after allogeneic hematopoietic stem cell transplantation
Creators Name:Szyska, M. and Na, I.K.
Abstract:The bone marrow is the origin of all hematopoietic lineages and an important homing site for memory cells of the adaptive immune system. It has recently emerged as a graft-versus-host disease (GvHD) target organ after allogeneic stem cell transplantation (alloHSCT), marked by depletion of both hematopoietic progenitors and niche-forming cells. Serious effects on the restoration of hematopoietic function and immunological memory are common, especially in patients after myeloablative conditioning therapy. Cytopenia and durable immunodeficiency caused by the depletion of hematopoietic progenitors and destruction of bone marrow niches negatively influence the outcome of alloHSCT. The complex balance between immunosuppressive and cell-depleting treatments, GvHD and immune reconstitution, as well as the desirable graft-versus-tumor (GvT) effect remains a great challenge for clinicians.
Keywords:GvHD, Bone Marrow, alloHSCT, Memory Niche, GvL, GvT, Bone Marrow Stroma
Source:Frontiers in Immunology
Publisher:Frontiers Media SA
Page Range:118
Date:30 March 2016
Official Publication:https://doi.org/10.3389/fimmu.2016.00118
PubMed:View item in PubMed

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