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IL-33 in T cell differentiation, function, and immune homeostasis

Official URL:https://doi.org/10.1016/j.it.2016.03.007
PubMed:View item in PubMed
Creators Name:Peine, M. and Marek, R.M. and Loehning, M.
Journal Title:Trends in Immunology
Journal Abbreviation:Trends Immunol
Page Range:321-333
Date:May 2016
Keywords:Alarmin IL-33, ST2/T1/IL-1RL1, CD4+ and CD8+ T Cell Subsets, Th1/Th2/Treg/CTL, T-bet/GATA-3/Foxp3, STAT4/STAT5, Animals, Mice
Abstract:Recent studies have highlighted a role for the alarmin interleukin (IL)-33 in CD4(+) and CD8(+) T cell activation and function, and have also revealed important distinctions. The IL-33 receptor ST2 is constitutively and abundantly expressed on T-helper-2 (Th2) and GATA-3(+) regulatory T cells in a GATA-3- and STAT5-dependent manner. Upon activation, Th1 and cytotoxic T cells express ST2 transiently, driven by T-bet and/or STAT4. We review these findings here, and critically examine evidence indicating that IL-33 enhances the differentiation and functionality of various T cell subsets through positive feedback loops involving lineage-specifying transcription factors. In this context, we discuss how quantitative and qualitative differences in ST2 expression between effector and GATA-3(+) regulatory T cells may contribute to immune homeostasis, and outline important areas of future inquiry.
Publisher:Elsevier (U.S.A.)
Item Type:Review

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