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Brain parenchymal damage in neuromyelitis optica spectrum disorder - a multimodal MRI study

Item Type:Article
Title:Brain parenchymal damage in neuromyelitis optica spectrum disorder - a multimodal MRI study
Creators Name:Pache, F. and Zimmermann, H. and Finke, C. and Lacheta, A. and Papazoglou, S. and Kuchling, J. and Wuerfel, J. and Hamm, B. and Ruprecht, K. and Paul, F. and Brandt, A.U. and Scheel, M.
Abstract:Objective: To investigate different brain regions for grey (GM) and white matter (WM) damage in a well-defined cohort of neuromyelitis optica spectrum disorder (NMOSD) patients and compare advanced MRI techniques (VBM, Subcortical and cortical analyses (Freesurfer), and DTI) for their ability to detect damage in NMOSD. Methods: We analyzed 21 NMOSD patients and 21 age and gender matched control subjects. VBM (GW/WM) and DTI whole brain (TBSS) analyses were performed at different statistical thresholds to reflect different statistical approaches in previous studies. In an automated atlas-based approach, Freesurfer and DTI results were compared between NMOSD and controls. Results: DTI TBSS and DTI atlas based analysis demonstrated microstructural impairment only within the optic radiation or in regions associated with the optic radiation (posterior thalamic radiation p < 0.001, 6.9 % reduction of fractional anisotropy). VBM demonstrated widespread brain GM and WM reduction, but only at exploratory statistical thresholds, with no differences remaining after correction for multiple comparisons. Freesurfer analysis demonstrated no group differences. Conclusion: NMOSD specific parenchymal brain damage is predominantly located in the optic radiation, likely due to a secondary degeneration caused by ON. In comparison, DTI appears to be the most reliable and sensitive technique for brain damage detection in NMOSD.
Keywords:Diffusion Tensor Imaging, Neuromyelitis Optica Spectrum Disorder, Optical Coherence Tomography, Demyelination, VBM Analysis
Source:European Radiology
ISSN:0938-7994
Publisher:Springer (Germany)
Volume:26
Number:12
Page Range:4413-4422
Date:December 2016
Official Publication:https://doi.org/10.1007/s00330-016-4282-x
PubMed:View item in PubMed

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